Omeprazole, pantoprazole and lanzoprazol differ in chemical structure, bioavailability, half-life, etc., but the results of their clinical application are almost identical.
Minimum inhibitory concentration for omeprazole is 25-50 mg / l, lanzoprazola – 0,78-6,25 mg / l, pantoprazole – 128 mg / liter.
Treatment regimes lanzoprazolom provide more early onset of clinical remission compared with omeprazole. The frequency of recurrence of peptic ulcers after treatment lanzoprazolom is 55-62%, pantoprazole – 55%, omeprazole – 41%.
Currently, long-term maintenance therapy allowed only omeprazole and lanzoprazol. Prolonged use (more than 5,5 years) omeprazole in patients does not lead to the development of neoplastic changes. In patients with peptic ulcer disease treated with supportive therapy of pantoprazole at a dose of 40-80 mg daily over 3 years, there was a small and statistically insignificant increase in the number of ECL-cells.
In contrast to omeprazole and lanzoprazola, pantoprazole significantly less interaction with cytochrome P-450.
Admission antacids, like food, does not affect the pharmacokinetics of pantoprazole. Sucralfate and food intake can alter the absorption lanzoprazola. Pharmacokinetics of omeprazole may be altered food intake, but does not change with liquid antacids. Therefore lanzoprazol and omeprazole are 30 minutes before meals, and pantoprazole – with or without food.
The cost of treatment:
Omeprazole
Omeprazole is a racemate. It contains a tricoordinated sulfur atom in a pyramidal structure and therefore can exist in equal amounts of both the S and R enantiomers. Price 21-day oral course of receiving omeprazole (20 mg / day) ranged from 60 (Omizak, Torrent) to 1470 (Loseke, Astra) rubles. In the lower price range (60-100 rubles per 21-day course) fall preparations: Omizak (Torrent), Zolser (Aurobindo Pharma), Zerotsid (Sun Pharm.), Romesek (Ranbaxy Labs.), Omez (Dr.Reddy’s Labs.), Omeprazole (Olaine CPP), omeprazole (Akrikhin), Vero-omeprazole (Styrene). Expensive (from 110 to 250 rubles) is a course of indian drugs Gastrozol (ICN October), omeprazole (KRKA), Omeprol (Zdravle). And, with the absolute separation leads Loseke firm Astra (price of the course 1250-1470 rubles).
Lanzoprazol
Lanzoprazol introduced in the market medications Lanzap firm Dr.Reddy’s Labs. (price 21-day course of 80-200 rubles) and Lansofed (Moshimfarmpreparaty, the price rate of about 240 rubles).
Omeprazole
Omeprazole
5-Methoxy-2-[[(4-methoxy-3, 5-dimethyl-2-pyridinyl) methyl] Sulfina] 1H-benzimidazole
Reference representative group – the drug company Loseke ASTRA (Sweden). Used by a substance is the standard of cleanliness, and used for oral administration in capsule form microgranules – stability. Botan company develop production technology Loseke provides very high stability performance solubility, absorption and bioavailability of omeprazole, which significantly affects the clinical efficacy of its application.
Pharmacological characterization
Has antiulcer effect. It has a high lipophilicity, easily penetrates the parietal cells of gastric mucosa, which accumulates and is activated by acidic pH. Inhibits H + K ATPase of the secretory membrane of parietal cells, stopping the output of hydrogen ions in the cavity of the stomach.
The following article was published by a Online Pharmacy Without Prescription.
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